Regulation on Cosmetic Products

Whether for quality control or research: PhytoLab is offering you an outstanding portfolio of highly purified phyproof® reference standards for your analysis and development of cosmetic products which must undergo a safety assessment before they are placed on the market.

The safety assessment includes an evaluation of all ingredients for substances restricted or prohibited by Commission Regulation (EU) 2024/996 amending Regulation (EC) No. 1223/2009 on cosmetic products.^[1^] These substances have allergenic properties or may pose a risk to human and animal health. Certain fragrance compounds may have allergenic properties and must be indicated on the container and packaging. The list of allergenic fragrances (Annex III) includes numerous ingredients of essential oils as well as many essential oils themselves, e.g., trans-Anethole, β-Caryophyllene, (-)-Menthol, α-Pinene, β-Pinene or α-Terpineol, as well as ylang-ylang, cinnamon oils, citrus oils, or peppermint oils.^[2,3]

Only recently, naturally occurring compounds with endocrine disruptor properties have been subject to scientific and regulatory scrutiny. The Scientific Committee on Consumer Safety (SCCS) has evaluated Resorcinol, and the isoflavones Daidzein & Genistein, constituents of soya or red clover extracts, for use in natural cosmetic products. Their maximum concentration in the ready to use preparation is specified in Annex III of Regulation (EC) No 1223/2009 with 0.007 % for Genistein and 0.02 % for Daidzein. From November 1, 2025, products containing Daidzein & Genistein have to meet these provisions.

Furthermore, p-Cymene occurring, e.g., in rosemary oil or tea tree oil is under scrutiny by European authorities and will possibly be classified as CMR Cat. 1b. We will keep you informed about the outcome and consequences.

Our fully documented high purity phyproof® reference standards of relevant substances for regulation on cosmetic products meet all the requirements for your quality control or research projects.

Find your compound below:

Name	CAS
Aconitine	302-27-2
Alizarin	72-48-0
Anthraquinone	84-65-1
trans-Anethole	4180-23-8
Aristolochic acid I	313-67-7
Aristolochic acid II	475-80-9
Benzyl alcohol	100-51-6
Bergapten	484-20-8
Brucine	357-57-3
DL-Camphor	76-22-2
Cantharidin	56-25-7
(-)-Carvone	6485-40-1
(+)-Carvone	2244-16-8
Catechol	120-80-9
β-Caryophyllene	87-44-5
Citral	5392-40-5
Colchicine	64-86-8
Convallatoxin	508-75-8
p-Cymene	99-87-6
Daidzein	486-66-8
Esculentoside A	65497-07-6
Genistein	446-72-0
Hydrastine	118-08-1
Hydroquinone	123-31-9
Imperatorin	482-44-0
Linalyl acetate	115-95-7
(-)-Menthol	2216-51-5
7-Methoxycoumarin	531-59-9
Methyl salicylate	119-36-8
Oleandrin	465-16-7
α-Pinene	80-56-8
β-Pinene	127-91-3
Pyrogallol	87-66-1
Resorcinol	108-46-3
Sesamol	533-31-3
Strychnine	57-24-9
α-Santonin	481-06-1
α-Terpineol	98-55-5
Theophylline	58-55-9
Trioxsalen	3902-71-4
Vanillin	121-33-5
Xanthotoxin	298-81-7

You need an analysis of your cosmetic products? We will be happy to provide you with our services. For further information, please contact: martin.mueller@phytolab.de

Literature

[1] https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R0996

[2] https://eur-lex.europa.eu/legal-content/DE/TXT/PDF/?uri=CELEX:32023R1545

[3] https://eur-lex.europa.eu/legal-content/DE/TXT/PDF/?uri=CELEX:02009R1223-20240404